The Asian & Pacific Islander American Health Forum (APIAHF), the NYU Center for the Study of Asian American Health (CSAAH), and the undersigned organizations who together represent the national collaborative of Asian American and Native Hawaiian and Pacific Islander (AA and NHPI) organizations who are the primary contractors with the Centers for Disease Control and Prevention (CDC) to respond to the COVID-19 pandemic, along with additional leading national and local AA and NHPI organizations across the country, submit this joint comment in response to the Preliminary Framework for Equitable Allocation of COVID-19 Vaccine (Draft Framework). As organizations representing communities that are the fastest growing groups in the United States (U.S.) and who have been and continue to be disproportionately impacted by COVID-19, it is vital that the Draft Framework explicitly address disparities in AA and NHPI communities in the development and deployment of COVID-19 vaccine distribution systems.